Background

https://askthescientists.com/neurotransmitters/

3. Dopamine

The most thrilling neurotransmitter has to be dopamine. That’s because it plays a major role in your brain’s reward system.

Dopamine floods the synapse between neurons when something rewarding happens. It’s responsible for that rush of joy when you accomplish a goal or succeed at a task. Dopamine perks your brain up and brings feelings of pleasure.

Some drugs prey on your brain’s reward system. They stimulate the brain to release an overabundance of dopamine. This creates a temporary sensation of pleasure, or a high. But coming down from a dopamine high is a hard fall. Afterward, you might feel depressed, tired, and less interested in your favorite activities.

Drugs aren’t the only way to mess with the normal dopamine levels in your brain. Addictive activities like video gaming, gambling, and shopping create similar highs. The surge of dopamine in your brain can make these habits hard to shake. That’s why it’s so important to understand how dopamine works so you can keep these behaviors in check.

Dopamine has plenty of positives, though. It encourages wakefulness. It helps your pancreas release the appropriate amount of insulin after you eat. Dopamine also coordinates your brain and your body to create voluntary movement. Writing your name, typing, and driving a car are all possible because of dopamine.

2017 paper by Peter A. Tass, followed by this  2018 paper, and this 2021 paper.  2021 article on a glove.  Tass interview, glove, patient experiences, and presentations by Tass.  

Sinamet - widely prescribed to Parkinson's patients to augment dopamine in the brain.

Dyskinesia - side effect of taking levodopa eg Sinamet and needs to be managed.